肿瘤的研究一直是生命科学和基础医学领域中的热门话题，随着分子生物学和肿瘤生物学等学科的发展，人们逐渐明确了一系列与肿瘤发生和转移等密切关系的基因、蛋白，包括多种受体酪氨酸激酶（RTKs，如EGFR、ALK、c-Met、TRK、BCR-ABL等）和非R ...

Receptor tyrosine kinases (RTKs) are pivotal in both normal cellular functions and cancer progression, activating critical signaling pathways. In cancer therapy, targeted therapies using monoclonal ...

RTKs can activate Ras, a protein that is tethered to the plasma membrane, by causing it to bind GTP. Once activated, Ras can do a variety of things. In this example, it activates an enzymatic ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?