Aberrant activation of the Src family of tyrosine kinases has been implicated ... of combination therapy with epidermal growth factor receptor inhibition and cytotoxic chemotherapy.

The ERBB receptors are a group of receptor tyrosine kinases (RTKs ... and all except ERBB3 have relatively active kinase domains. Although ERBB2 is minimally active in ligand binding, it is ...

The latter is known as tyrosine kinase, which isn't the ... deficient in different members of the JAK family. They found that the interferon-alpha receptors were not restricted to activation ...

Bruton’s tyrosine kinase (BTK) kinase is a member of the TEC kinase family and is a key regulator of the B-cell receptor (BCR)-mediated signaling pathway. It is important for B-cell maturation ...

or other solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation. The study, published Dec. 9 in the Journal of Clinical ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Research Progress of c-Kit in Platinum-Resistant Ovarian Cancer. Journal of Biosciences and Medicines, 13, 404-412. doi: 10.4236/jbm.2025.132030 . According to the date from Chinese Center for Disease ...