Factors found to be amplified in human tumors are indicated in green and those found to be frequently lost are indicated in red. Black lines indicate direct activation (arrowheads) or inhibition ...

The transduction of extracellular signals across the membrane to initiate complex cascades of molecular events regulates numerous vital cellular processes. The molecular basis of ...

Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling ... tropomyosin receptor kinase A, or TrkA.

His research focuses on elucidating the role of receptor tyrosine kinase in the invasion and survival of glioblastoma (GBM). He is also interested in exploring the interplay between kinase signaling ...

Preliminary data from the first-in-human study presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting demonstrated that CS5001 is well-tolerated and exhibits encouraging ...

Sunshine Lake Pharma Co Ltd. has divulged non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of multiple sclerosis, psoriasis, rheumatoid arthritis, atopic ...

Tyrosine kinase inhibitors (TKIs) are a class of targeted cancer therapies designed to block the action of tyrosine kinases, enzymes that play a key role in cellular functions such as growth, division ...

As a non-receptor tyrosine kinase, TYK2 is a member of the JAK kinase family, which is an important kinase on the JAK-STAT signaling pathway and plays an important role in the pathogenesis of ...

NEU-111 is a potent and highly selective oral allosteric inhibitor of tyrosine kinase 2 (TYK2), a JAK ... as a critical modulator of immune signaling pathways. Importantly, we see significant ...