Hypertension (high blood pressure) affects an estimated 1 billion people worldwide and approximately 65 million people in the US alone. If not treated effectively, this common disorder can lead to ...

Advocates of measuring plasma renin activity argue that this approach leads to individualized treatment, which is more likely to lower BP in a timely manner with fewer drugs. [1] Additionally ...

Most antihypertensive drugs target the renin-angiotensin system and fall in two drug classes: angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). ACE cleaves a ...

The effects of SGLT2 inhibitors on the kidney to prevent progression of chronic kidney disease, congestive heart failure, ...

Hypertension is typically treated with medications like diuretics, ACE inhibitors, beta-blockers, calcium channel blockers, ...

If the clinical history is not helpful (e.g., there is no documentation of the efficacy of drug "A"), then measuring a renin level (either plasma renin activity or direct renin) can be helpful ...

The consequences of primary aldosteronism mainly result from the activation of the mineralocorticoid receptor. Two of these ...

UVA researchers found that the drugs essentially rewire the kidneys to do something other than the important work of filtering blood. The kidneys start producing more of a hormone called renin ...

However, 3 decades would elapse before it was applied to unraveling the biochemical vocabulary of the alternative arm of the renin-angiotensin system (RAS) counteracting Ang II (angiotensin II) ...

Churchwell said the drug class slows the heart by inhibiting ... increasing pumping force and releasing a kidney enzyme called renin. Cardioselective beta blockers acebutolol, atenolol, betaxolol ...

Renin–angiotensin system (RAS) inhibitors could potentially improve cardiac remodelling ... Follow-up was complete for dispensed medication and events during the study period. In Sweden, chronic ...