This means the other half of the cells with a wild-type copy of MECP2 inherited from the other parent expresses normal MeCP2 ...

This is supported by the observations that in mice MECP2 is expressed prior to synaptogenesis so that, presumably, the MECP2-deficient Rett syndrome brain would have fewer synapses. The animal ...

Mesci then added healthy microglia to the Rett syndrome brain organoids and found that the functioning of synapses—where neurons connect and communicate—was "rescued." This occurred due to the ...