为探究 MDA5 在皮肌炎（DM）血管损伤中的作用机制，研究发现 MDA5 蛋白介导的内质网应激 / 未折叠蛋白反应（UPR）促进血管内皮细胞向间充质细胞转化（EndMT），这与 MDA5 + DM 相关间质性肺病（ILD）有关。 皮肌炎（Dermatomyositis，DM）是一种特发性炎症性肌病 ...

Several 'sensors' of RNA, including Toll-like receptors (TLRs) and the RNA helicases RIG-I and Mda5, have been shown to be essential for innate immune responses to many types of pathogens.

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and ...

This phenomenon, they argue, likely indicates “a distinct form of MDA5+ disease in the Covid-19 era,” which they have labelled “MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous ...