Use of liposome fusion to introduce a form of SOD1 that contains the catalytic copper, but depleted of structural zinc, has led to an alternative oxidative explanation 4.Specifically, SOD1 mutants ...

This theory is supported by a vast body of experimental evidence demonstrating that aerobic organisms first chronically generate powerful pro-oxidant species (reactive oxygen species; ROS); second ...

These changes lead to ROS accumulation, energy depletion ... including TAR DNA-binding protein 43 (TDP-43), superoxide dismutase 1 (SOD1), and C9orf72, have been reported to physically interact ...