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Sirt6 缺失激活 Got1,通过异常激活糖酵解导致腭裂:揭示腭裂发生的 ...
为探究腭裂(CP)发病机制,研究人员聚焦 Sirt6,发现其缺失激活 Got1,影响腭发育,为 CP 防治提供新靶点。 腭裂是一种常见的先天性颅面畸形,不仅影响面部美观,还会给患者的饮食、听力和心理健康带来诸多困扰。目前,普遍认为腭裂是由遗传和环境因素 ...
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