近期在《International Journal of Oral Science》上发表的一项研究中，科研团队利用单细胞RNA测序（scRNA-seq）技术，深入探讨了头颈部鳞状细胞癌（HNSCC）的免疫微环境，揭示出了以B细胞为主导的免疫亚型，并构建了基于B细胞激活的预后风险模型。

该研究系统性阐释了非小细胞肺癌患者在新辅助免疫治疗联合化疗后的免疫微环境异质性，识别了患者在耐药机制方面的潜在差异，并开发了预测患者复发风险的新型生物学标志物，具有一定的基础研究与临床转化价值。

Single-cell gene sequencing has changed the way scientists understand life at the smallest level. It lets researchers study ...

常规通路分析如同根据书脊判断内容，scNET则能逐页精读。在脑肿瘤微环境研究中，传统方法漏掉了70%的低丰度信号通路。而通过整合PPI网络，scNET不仅捕捉到Wnt、Hippo等经典通路，还发现了全新的"代谢-免疫"交互轴心。

研究结论表明，高 ESM1 表达的 EC 亚群与膀胱癌的临床结局和免疫特征密切相关，靶向肿瘤相关 ECs 中的 ESM1 可能是治疗膀胱癌和增强抗肿瘤免疫的有前景的策略。同时，研究人员构建并验证了与 MIBC ...

The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...

研究人员针对单细胞 RNA 测序（scRNA-seq）数据整合和查询问题，评估多种特征选择方法，发现高变特征选择表现出色，为相关研究提供重要指导。 在生命科学领域，单细胞转录组学技术的兴起为构建参考细胞图谱带来了新的契机。通过单细胞 RNA 测序（scRNA-seq ...

Using single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq), researchers profiled more than 13 million cells and nuclei, covering hundreds of individually dissected brain regions ...

The "RNA Analysis Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2020-2030F" report has been added to ResearchAndMarkets.com's offering.The Global RNA Analysis Market was ...

The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...

Single cell RNA sequencing (scRNA-seq) provides the resolution and scale to unravel the complexity of cancer biology and reveal insights to advance human health. Join Dr. Allison Stewart and Dr. Carl ...