What are the activation mechanisms particular to ERBBs ... This phenomenon is called transmembrane signaling, and it comes in many forms and subtypes. Transmembrane signaling systems include ...

We have been comparing signaling pathways activated in ET cell ... As expected, we found that monolayer ET cells show serum-dependent activation of ERK 1/2 and p38 MAP kinases.

Key among these is the activation of signaling by RHO (another member of the RAS superfamily) and the up-regulation of kinases, some of which have the same substrates as ERK. Studies are needed to ...