Horror. However, on occasion, a horror movie breaks through. The Silence of the Lambs is as unsettling a movie as you will find, but it was also a critical darling that spawned multiple sequels ...

The Silence of the Lambs, the 1991 film by Jonathan Demme, and the only pure horror film in history to win an Academy Award ...

Technically, The Silence of the Lambs is not a sequel in the conventional sense, but, given that it chronologically takes place after Red Dragon and Hannibal Rising, it can work within this list.