Results: The double-drug regimen given for 12 months to four different groups, according to the different combined dosages of simvastatin ... with normal hepatic and renal function.

Severe renal impairment (CrCl <30mL/min): reduce clarithromycin dose by ½. When moderate or ... metabolized by CYP3A4 (lovastatin or simvastatin). Concomitant colchicine (in renal or hepatic ...