Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

as well as on the pathological effects of β-myosin mutations causing cardiac and skeletal myopathies. I primarily use live-cell imaging to study the proper incorporation of WT and mutant fluorescent ...

Cardiac muscle co-expresses N2B and N2BA isoforms, skeletal muscle has N2A isoform only. Elastic region of titin. A particularly important property of titin filaments is their ability to act as ...