前期研究发现姜黄素吡咯烷衍生物 DMC-BH 虽有抗 GSCs 活性，但存在效力有限、代谢快、脑靶向性不足等问题。为突破困境，研究人员巧妙设计，以 “封闭代谢位点” 策略对其改造，将 DMC-BH 与葡萄糖相连，打造出新型脑靶向分子 DMC-GF，一场探索 DMC-GF 治疗胶质瘤 ...

Now, researchers at Nanjing University, China have confirmed this link by focusing on a protein whose levels are reduced in many patients with congenital heart defects, called SLC25A1.