A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound ...

Extracting exons from pre-mRNA and splicing them together to create mRNA requires, first and foremost, a mechanism for distinguishing exons and introns. Intron recognition always takes place ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...

The Fugu genome contains all the alternative promoters and splice exons and introns present in mammalian genomes, but because the introns are so much smaller, genes are about an eighth the size, says ...

was able to dig through a huge amount of genetic data to identify splicing events that may give cancer a better chance to grow. In small-scale lab tests on tissue samples, targeting these exons ...