Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in RNA molecules is a formidable task, especially when the RNAs reside within large, dynamic ...

The spliceosome edits genetic messages transcribed ... the expression of SF3B1 in cancer cells sets off a cascade of events ...

New work suggests that Prp8, a highly conserved protein in the heart of the spliceosome, both orients the substrate and participates in catalysis. The U5 snRNP functions in spliceosome assembly as ...

The spliceosome edits genetic messages transcribed from DNA ... The study found that altering the expression of SF3B1 in cancer cells sets off a cascade of events that affected a third of the cell’s ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins ...