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揭秘前列腺癌:SREBF1如何重塑代谢并影响铁死亡抵抗,为抗癌带来新 ...
同时,SREBF1 阳性细胞中,与铁死亡相关的 SCD、FASN 等基因以及参与抗铁死亡机制的 AR 和 MBOAT2 都显著上调,胆固醇合成途径在 SREBF1 阳性组也高度激活。 单细胞测序 hdWGCNA 分析也揭示了重要信息。通过 hdWGCNA 分析上皮细胞亚群,研究人员发现与 SREBF1 活性相关性 ...
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