A groundbreaking clinical trial in Japan has achieved a significant breakthrough in stem cell therapy ... a disorder that leads to scarring on the cornea, were included in the study.

The innermost layer of the cornea, consisting of a single layer of cells that regulate fluid and maintain corneal transparency. Human Pluripotent Stem Cells (hPSCs): Stem cells that can ...

James Funderburgh, PhD, at the University of Pittsburgh discovered stem cells in the corneal stroma in an effort to use these cells to reduce corneal scarring. In early animal studies and ...

The limbus, the area where the cornea meets the sclera, provides a specialized environment that supports these stem cells. When this environment is disrupted, it can result in corneal scarring ...

The team, led by Professor Koji Nishida, used induced pluripotent stem cells (iPS) to perform corneal ... the cornea cannot regenerate and repair the surface, leading to the formation of scar ...

BACKGROUND: Radiation therapy can cause corneal and conjunctival abnormalities that sometimes ... CONCLUSION: Radiation therapy in this patient caused temporary stem cell dysfunction which resulted in ...

Over 3.2 million people worldwide are bilateral blind from corneal diseases. Limbal stem cell ... the cornea surface will become opaque. Corneal transplant can’t survive and is contraindicated in LSCD ...

These data will provide foundational proof-of-concept data that will allow the rapid advance of a cell therapy towards clinical application. Determine optimal conditions to generate human corneal ...

Transplanting corneal cells made from human induced pluripotent stem ... treatment that could overcome the challenges that existing treatment has faced, such as a shortage of cornea donors ...

This is a condition known as corneal epithelial stem cell deficiency, and it can lead to vision loss and, in particularly serious cases, blindness. Previously most attempts to replace the cornea ...