including cancer-induced insoluble fibrin, and then created an antibody drug conjugate using the antibody that especially targets those refractory, stroma-rich cancers.” One new antibody therapy ...

Understanding the molecular cross-talk that occurs within the microenvironment between tumor cells and the ECM/other stromal cells may point to opportunities for cotargeting of the tumor and ...

Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors and were among the first solid tumor types for which such a novel treatment (in this case imatinib) became available. The ...

Molecular Profiling of Biliary Tract Cancers in African American and Caucasian Patients Less than 5% of GI stromal tumors (GISTs) are driven by the loss of the succinate dehydrogenase (SDH) complex, ...