相关研究结果于2025年2月7日在线发表在Cancer Discovery期刊上，论文标题为“Survivin Promotes Stem Cell Competence for Skin Cancer Initiation”。 论文共同通讯作者 ...

Survivin is a functionally distinct member of the IAP family, with only a single BIR motif at its N-terminal half 9.The human survivin gene is abnormally over overexpressed in many forms of cancer ...

Small molecule inhibitor of survivin dimerization for the treatment of solid tumors. Survivin, a homodimeric member of the Inhibitor of Apoptosis Protein (IAP) family, is required for cancer cell ...

The company’s lead agent, SurVaxM, targets survivin, a cell-survival protein expressed in cancer cells. Glioblastoma (GBM) is a fast growing and aggressive brain cancer that has a high mortality ...

They were thus able to identify several genes that were upregulated (overexpressed) in the activated stem cells, and this is what put them on the track to finding Survivin, also known as BIRC5.