However, functional analysis and in vivo transfer of MHC multimer-stained cells is hampered by the persistence of T-cell receptor (TCR)–MHC interactions and subsequently induced signaling events.

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional ...

Discovering antigen-reactive T cell receptors (TCRs ... to antigen peptides presented by major histocompatibility complex (MHC) molecules, triggering a cascade of cellular responses that lead ...

Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of Natural Killer (NK) cells and a minority of T cells. They ...

(2023) Facile repurposing of peptide-MHC restricted antibodies for cancer immunotherapy ... Garcia KC. (2022) Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature. 612, ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

However, the structure of these receptors is generally poorly understood, which can have a substantial impact on therapeutic performance. In the example of CAR T-cell therapies, structurally ...

Cite this: Human Mannose Receptor ... MHC class II and cross-presentation pathways in vivo and thus involve both humoral and cellular arms of immune response. Estimation of the role of dendritic ...