Ishii and colleagues now reveal that TBK1 (TANK-binding kinase 1) mediates the adjuvant effect of DNA vaccines and that this effect occurs independently of the TLR (Toll-like receptor) signalling ...

在透明细胞肾细胞癌（ccRCC）的发展代谢失调仍有待了解。在这里，作者发现抑制TBK1-mTORC1信号传导和糖酵解的肉碱合成酶BBOX1在ccRCC中经常丢失。 肾透明细胞癌研究新突破：BBOX1 的抑癌机制解析 美国德克萨斯大学西南医学中心病理学系的研究人员在《Nature ...

By inhibiting the function of TBK1, a gene previously associated with immune evasion, we were able to restore CAR-T cell activity, prevent dysfunction and increase T cell proliferation.