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16 天
III型干扰素通过TLR7激活增强pDC功能并拮抗TGF-β和PGE2介导的免疫抑制
法国研究团队发现cDC1分泌的III型干扰素(IFN-III)能通过上调TLR7表达增强pDC对TLR7激动剂的响应,并逆转TGF-β/PGE 2 的抑制作用,恢复IFN-α分泌能力。该研究为联合IFN-III与TLR7激动剂的肿瘤免疫治疗提供了新思路,发表于《Nature Communications》。 在肿瘤免疫治疗领域 ...
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