TNF was first described by Lloyd Old and colleagues as a protein produced in lipopolysaccharide-challenged animals and was believed to be responsible for the hemorrhagic necrosis of certain ...

But it was only in 1984 that research into TNF really began to take off. “The decade-long effort to purify tumor necrosis factor finally culminated in 1984 with the cloning of the gene, the ...

Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.