Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.

Researchers have uncovered mechanisms by which mobile genetic elements integrate into the chromosomes of bacteria with linear genomes.

During DNA replication, the unwinding of strands leaves ... Interestingly, this phenomenon is also present at unprotected telomeres (chromosome ends) that contain ssDNA (Figure 3).

a converging fork will complete replication. However, if a single fork stops within the rDNA or telomere, it will result in a region of DNA that cannot be replicated. Therefore, the rDNA ...

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a ...

the cells would destroy the DNA or turn the linear fragments into circular molecules. But when Szostak and Blackburn tacked on the repetitive Tetrahymena end-sequences to these linear DNAs, they ...

Donald Coffey, a longtime professor at Johns Hopkins University, discovered the nuclear matrix within cells and its role in DNA replication. Telomeres are repetitive, noncoding sequences that cap the ...

I am studying the protein complex CST which is essential in Telomere replication and upkeep, as well as having functions more broadly in DNA replication and repair. I am interested in how the ...

The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and ...

Dysregulated R-loops can cause stalled replication forks and telomere ... triggering the accumulation of R-loops at telomeres. This accumulation induces DNA damage response (DDR) and telomere ...