The evidence supporting the relevance of replicative senescence of human cells and telomere biology to human cancer is now quite strong. The evidence linking replicative senescence to human aging ...

This part of our chromosomes can influence the ageing process, and possibly the development of chronic diseases.

He treated the cultured myeloma cell lines U266 and CAG (which have short telomeres) and SKO-027 (which ... to kill a variety of cancer cell types in vivo.

Telomerase Inhibition for Cancer Treatment ... as murine cell chromosomes have much longer telomeres than those of humans. Some researchers argue that telomerase inhibitors could turn out to ...

E.H. Blackburn et al., “Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging,” Nat Med, 12:1133-38, 2006.] Telomere lengthening in cancer cells, however, ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this ...

8 The observed association between shorter telomeres and increased risk of cancer, cardiovascular disease, and neurodegenerative disorders emphasizes the importance of telomere length measurement.

Key areas of focus include studying how short telomeres reduce the likelihood of developing cancer and influence human lifespan, as well as exploring strategies to extend individuals’ health ...

A new proteomic aging clock may predict biological age, mortality risk, and the likelihood of age-related diseases, though ...

An enzyme that helps maintain telomere length. In most human cells, telomerase is inactive after early development, but it remains active in cancer cells, allowing them to divide indefinitely. Mice ...

Shortened telomeres have been linked to various age-related diseases, including cancer, osteoarthritis, and heart disease. Conversely, longer telomeres are thought to allow cells to divide more ...