Osteoclasts play a crucial role in bone remodeling by breaking down bone tissue. Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The ...

Skeletal remodeling is mediated by the integrated and tightly coupled actions of mechano-sensing osteocytes, bone-resorbing osteoclasts and bone-forming osteoblasts (Figure 1).

[10] To further halt bone resorption, a decoy protein, osteoprotegerin, is secreted from osteoblast precursors, causing osteoclasts to undergo apoptosis or move to another remodeling site.

Yamada et al. evaluated the performance of serum tartrate-resistant acid phosphatase 5b (TRACP5b), a biochemical marker for bone resorption, in comparison with established markers in the ...

On cessation of lactation, levels of PTHrP and RANKL and the rate of bone resorption decrease (not shown). Babey et al. 3 recently described a mechanism of skeletal recovery (Panel B). Kisspeptin ...