免疫荧光技术：检测细胞内蛋白的定位和表达情况，通过计算 YAP 在细胞核与细胞质的荧光强度比值，评估其核定位情况；利用该技术还可观察 TRAIL - R2/DR5 的聚集情况。 荧光素酶报告基因检测：采用 8xGTII–lux 荧光素酶报告基因检测 YAP/TAZ - TEAD 的转录活性 ...

In addition, DR5 TRAIL variant expressing NK cells may also be less susceptible to rejection as they can eliminate DR5-positive alloreactive T cells. ONK’s most advanced candidate is ONKT101 ...

The researchers describe how they used sEVs, which are engineered in the lab from human cells, to target a cell-surface receptor called DR5 (death receptor 5) that many tumor cells have.