Mitochondrial deoxyribonucleic acid (mtDNA) is essential for cellular energy production and overall cell function.

If DNA is a book, then how is it read? Learn more about the DNA transcription process, where DNA is converted to RNA, a more portable set of instructions for the cell. The process of transcription ...

In the absence of sigma, transcription initiation forms harmful R-loops unless RapA can intervene first, prying open the RNAP clamp. "RNAP is like a big claw that closes around DNA," Darst says.

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

Our lab is using a variety of biochemical, cellular, and biophysical methods to better define how Mediator, TFIID, and TFIIH work together with other PIC components to regulate pol II transcription ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...