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Treg 来源的双调蛋白对狼疮性肾炎的保护作用:机制新探与治疗新希望
缺乏 Tregs 来源 AREG 的小鼠,其肾脏和脾脏中的效应 T 细胞(Teff)的促炎细胞因子表达并未增加,甚至在 12 个月时肾脏 Teff 的 IFNγ 分泌略有降低,且巨噬细胞的 M1/M2 极化也未受明显影响。这表明 Tregs 来源的 AREG 对 CD4 + Teff 或巨噬细胞的激活和细胞因子分泌没有 ...
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