Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells.

Ovarian cancer (OC), the most lethal gynecological malignancy, is the fifth leading cause of cancer-related death in women.

However, while existing drugs called tyrosine kinase inhibitors (TKIs) are effective initially, resistance inevitably develops, leaving patients with limited options. EGFR mutations, including L858R ...

National University of Singapore (NUS Medicine), researched how tiny particles released by cancer cells, known as tumor-derived extracellular vesicles (TDEs), communicate with surrounding cells ...

“[It is] interesting work that further highlights the complex intercellular crosstalk between stromal cells in cancer,” said Giulia Biffi, a cancer biologist at the University of Cambridge who was not ...

Researchers identify mitochondrial transfer between cancer and immune cells as a crucial mechanism for immune evasion. The ...

Because these small, cellular vehicles carry contents from their parent cells, exosomes can serve as snapshots for a given population of cells, including tumors. “If you can sample a vesicle, or any ...

which are composed of spindle cell stroma and benign epithelial elements. The most common site of origin of these tumors is the breast, followed by the prostate and, rarely, the seminal vesicles.

M1 Macrophage-Derived Exosomes: These vesicles exhibit anti-tumor properties by delivering miRNAs that inhibit oncogenic pathways in HCC cells. Cancer-Associated Fibroblast (CAF)-Derived Exosomes ...

Aethlon Medical, Inc. (Nasdaq: AEMD), a medical therapeutic company focused on developing products to treat cancer and life-threatening infectious diseases, today announced a significant milestone: ...