Objectives: After completion of this article, the reader should understand (1) the theories of causation of biliary atresia, (2), the data supporting involvement of viral infection in pathogenesis ...

The underlying stimulus for the immune-mediated bile duct injury in biliary atresia may involve an insult (e.g., viral infection) to the bile duct epithelium that leads to upregulation of ICAM and ...

Lithocholic acid (LCA) is a hepatotoxic compound. Fetal LCA might play a role in the pathogenesis of neonatal cholestasis/EHBA. Recent results show that fetal liver has capacity for hydroxylations ...