Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

TAUSSIG: a multicenter, open-label study to assess the long-term safety, tolerability, and efficacy of AMG145 on LDL-C in subjects with severe familial hypercholesterolemia Clinical Phase II study ...

Dear Reader: Familial hypercholesterolemia ... More specifically, FH results in very high levels of a type of cholesterol known as low-density lipoprotein, or LDL. This puts people living with ...

Cholesterol is majorly of two types: LDL (low density lipoprotein ... This condition is known as Familial Hypercholesterolemia (FH), it is a genetic disorder that leads to abnormally high levels ...

Homozygous Familial Hypercholesterolemia (HoFH) is a rare genetic disorder and most severe form of Familial Hypercholesterolemia (FH), characterized by reduced hepatic clearance and resultant ...