The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

The non-receptor tyrosine kinase Src is important for many aspects ... but also as an entry point into the molecular genetics of cancer.

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected proteins. In the Eph SAM dimer structure ... compose the molecular interaction surface.