Conversely, PDGFRB is a receptor tyrosine kinase that is normally repressed in lymphocytes, yet PDGFRB remains a common fusion partner in leukemias. Here, we demonstrate that the EBF1-PDGFRB ...

a tyrosine kinase domain and a SAM (sterile α motif) domain. Two groups of researchers have recently determined crystal structures of two isolated Eph receptor domains — the SAM domain (page 44 ...