你是否见过这样的孩子？他们拥有天真烂漫的笑容，纯洁如天使，被唤作“微笑天使”。 然而，笑容背后却往往伴随错乱言语和僵硬颤抖的步伐，如同被操控的“快乐木偶”，空洞微笑摇摆。这并非真快乐，而是一种罕见病——天使综合征（Angelman Syndrome, AS）的残酷伪装。

Angelman syndrome is caused by a large deletion of the region of the maternal chromosome that contains UBE3A, or by a DNA sequence change (mutation) in the UBE3A gene inherited from the mother.