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2 天
RNA结合蛋白IGF2BP3通过稳定LDHA mRNA重塑血管内皮细胞糖代谢以抵御ox-LDL ...
本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题,研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA,从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制,显著减轻内皮细胞凋亡。该发现为心血管疾病 ...
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