Selective protein degradation by the ubiquitin–proteasome ... the fundamental sequence of events leading to protein ubiquitination, and also identified the essential factors necessary for ...
“Protein degradation is based on intracellular processes ... with poly-ubiquitin – a peptide marker or ‘magic protein’ that flags them for destruction by proteasomes. "Hijacking the natural ...
a protein involved in PER degradation, and Lys1117 and Lys1118 are key ubiquitination sites critical for maintaining PER stability. Aspirin is a potent lysine acetylation inducer, but its impact ...
A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...
We develop chemical approaches for protein ubiquitination, activity-based Ub probes and inhibitors against deubiquitinases (DUBs). We also develop new PROTAC (proteolysis-targeting chimera) strategies ...
This connection between ALG2 and COPII starts a process called ubiquitination, which is involved in protein degradation. A ...
Discover why the ability to pharmacologically degrade fat mass and obesity-associated protein represents a promising avenue ...