In most mammals uric acid is promptly converted to allantoin by uricase, but man possesses no uricase in the tissues; hence, uric acid is the final product of the oxidation of purines, except for ...

developed a polyethylene-glycol-modified recombinant mammalian urate oxidase (PEG-uricase) for this indication ... refractory gout and a plasma uric acid concentration (pUAc) of >7 mg/dl.

Uricase degrades relatively insoluble uric acid to the more soluble compound allantoin. Urate reabsorption by urate transporter-1 is partly suppressed at the proximal tubule lumen membrane by the ...

Uric acid is naturally present in the body ... which reduce urate production Uricase, which breaks urate down to make it ...

Medications are often prescribed to help lower uric acid levels in the body. These can include: Xanthine oxidase inhibitors ...

An increase in uric acid has become a common problem nowadays, which can cause problems like joint pain, swelling and difficulty in walking. If it is not controlled in time, it can cause serious ...

Arthritis Care Research News Alerts. 2007;57(5):816-821. High uric acid levels in the blood are a precursor of gout, the most common inflammatory arthritis in adult men. It is believed that coffee ...