In most mammals uric acid is promptly converted to allantoin by uricase, but man possesses no uricase in the tissues; hence, uric acid is the final product of the oxidation of purines, except for ...

developed a polyethylene-glycol-modified recombinant mammalian urate oxidase (PEG-uricase) for this indication ... refractory gout and a plasma uric acid concentration (pUAc) of >7 mg/dl.

Uricase degrades relatively insoluble uric acid to the more soluble compound allantoin. Urate reabsorption by urate transporter-1 is partly suppressed at the proximal tubule lumen membrane by the ...

There are several tests used to measure uric acid levels in the body: This blood test measures the amount of uric acid in the blood. It's the most common method for diagnosing hyperuricemia ...

Medications are often prescribed to help lower uric acid levels in the body. These can include: Xanthine oxidase inhibitors ...

If approved, Sobi and Selecta’s drug candidate will be a rival to Horizon Pharma’s FDA-approved Krystexxa (pegloticase), a uricase enzyme used to break down uric acid. The drug is administered ...

SEL-212 is based on a uricase enzyme (pegadricase) that breaks down uric acid in the blood combined with an immune tolerance component (ImmTOR) designed to prevent the formation of antibodies ...