在大脑的 “记忆中心”—— 海马体中，齿状回（DG）区域藏着神经干细胞（NSCs），它们如同大脑的 “种子”，不断产生新神经元，对海马的记忆和情绪调节功能至关重要。一直以来，血管内皮生长因子（VEGF）被认为在成年海马神经发生中扮演重要角色，过往研究发现，它能促进 NSCs 增殖，还和 NSCs 与血管的邻近关系有关。可关于 VEGF 如何调控 ...

These findings suggest that, although VEGF signaling may be a rate-limiting step in a wide variety of circumstances, local regulatory pathways modulate endothelial-cell growth and function in a ...

Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors—thereby regulating VEGF-induced ...

这篇综述通过系统分析发现，VEGF-A 水平与 COVID-19 严重程度相关，或可作预后指标。 一、研究背景 新型冠状病毒（SARS-CoV-2）引发的 2019 冠状病毒病（COVID-19）自 2019 年爆发以来，迅速演变成全球性健康危机，给人类生命和社会经济带来了沉重打击。该病毒主要 ...

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Leap Therapeutics' Phase 2 trial data show sirexatamab boosts response rates and survival in MSS colorectal cancer, with ...

Our study suggests that activation of VEGF-B signaling in white adipose tissue and the kidney together contributes to higher release of fatty acids into the blood, leading to increased lipid ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Anti-VEGF therapy improves outcomes in retinal diseases by targeting neovascularization and macular edema, crucial in conditions like AMD and diabetic retinopathy. Optical coherence tomography is ...

Adding the VEGF inhibitor ramucirumab (Cyramza) to the EGFR inhibitor osimertinib (Tagrisso) slowed progression of untreated EGFR-positive non-small cell lung cancer (NSCLC) by 9 months compared ...