in 31 countries to receive the angiotensin-receptor blocker valsartan or the calcium-channel blocker amlodipine. Doses were titrated over 6 months (daily maximums, 160 mg and 10 mg, respectively ...

160 mg, or 320 mg valsartan daily; 200 mg AHU377 daily; or placebo. Dosages were chosen so that patients treated with the low, medium, and high doses of LCZ696, respectively, would have the ...