枸橼酸西地那非片俗称“伟哥”，“伟哥”的诞生来源于一次失败的临床试验，枸橼酸西地那非片的前身是一种名为UK-92480的化合物，UK-92480化合物最初研究的目的是要通过抑制人体内的磷酸二酯酶-5（PDE-5），使体内的cGMP升高，引起心血管舒张 ...

The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular and vascular penile ...

PDE inhibitors, in particular the PDE5 (cyclic GMP PDE) inhibitors avanafil, lodenafil, sildenafil, tadalafil, udenafil and vardenafil, are regarded as efficacious, having a fast onset of drug ...