Scartozzi et al. studied EGFR status and expression of the EGFR downstream kinases phosphorylated Akt and MAPK in primary colorectal tumors and their corresponding metastatic sites in order to ...

Targeting receptor ... (EGFR *). In U87MG cells, MET is phosphorylated and bound to GAB1, but expression of wild-type EGFR and EGFR * displaced MET from the GAB1–PI3K complex. Downstream ...

activation of alternative tyrosine kinase receptors that bypass the EGFR pathway; (iii) independent or constitutive activation of intracellular molecular effectors downstream to EGFR; and (iv ...

(Cited in 98 papers) Gavin MacBeath's team at Harvard University wanted to find the proteins that get recruited to receptors in the first step of epidermal growth factor signaling. Using microarrays ...