STR 检测证实 iPSCs 来源于患者，支原体检测显示无污染，核型分析表明染色体数目和结构正常。此外，iPSCs 表达干细胞标记物 SSEA4、OCT4 和 NANOG，且具有良好的三胚层分化能力，这意味着这些 iPSCs 具有多能性，为后续的研究奠定了坚实基础。 血管类器官的形成与 ...

为探究 Nanog 对软骨细胞的作用，研究人员发现其诱导软骨细胞去分化，且受 p53/KLF4 和 p38/AKT 通路调控。 同源盒蛋白 Nanog 是转录因子家族的成员，在维持胚胎干细胞（ESCs）的多能性和自我更新方面发挥着至关重要的作用。由于其功能多样，Nanog 在多种细胞类型 ...

Subsequent work by James Thomson and colleagues replicated Yamanaka's success with human cells and revealed additional factors—Nanog and Lin28 ... most researchers making iPSCs are sticking ...

New methods for deriving macrophages from induced pluripotent stem cells are easier to scale and provide more clinically relevant data. Induced pluripotent stem cells (iPSCs) have given scientists ...

“And it turned out these were fantastic for making iPSCs.” Suddenly, the opportunities for iPSC derivation and banking seemed endless. The question, of course, was how to pick which lines to derive ...

The urgent need for better human disease models in drug discovery is increasingly recognized, with human iPSCs playing a crucial role in developing physiologically relevant in vitro models for ...