Much remains to be learned about mtDNA, however, and continued study of this fascinating genome will continue to expand our understanding of human disease and human history for years to come.

However, progress towards therapies and prenatal diagnosis of mtDNA diseases has been severely impeded by the lack of a mouse model of mtDNA disease: direct manipulation of the mtDNA of mammals is ...

Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the ...

A new discovery in blood immune cells has put researchers one step closer to identifying a blood biomarker that would allow doctors to personalize treatments for Parkinson's disease.

Mitochondrial diseases, which represent some of the most ... alongside a significant reduction in mtDNA levels. When the mtDNA in the liver tissue removed during the transplant was quantified ...

Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how mitochondrial DNA (mtDNA) contributes to cancer has been unclear. Scientists at ...

A new partnership between the Sheffield Institute for Translational Neuroscience (SITraN) and Nanna Therapeutics will advance mitochondrial drug discovery research for neurodegenerative diseases.