根据美国杂草科学协会（WSSA）的调查，地肤草已成为谷物、玉米和高粱种植者面临的主要杂草之一，尤其在休耕期，其防控需求尤为迫切。科罗拉多州立大学和堪萨斯州立大学的杂草科学家研究表明，地肤草对草甘膦、麦草畏、2,4-D和氟草烟的抗性在多个种群中已得到验证。此外，对多种除草剂产生抗性的地肤草生物型近年来显著增加。

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