Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

there is little doubt that the globular head domain of myosin II, seen as a cross-bridge between actin and myosin filaments in muscle, acts as the motor domain of the molecule and pulls actin ...

In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow and fast-moving formin would adopt different shapes at the filament.

In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow ...

Their work, published in Nature Communications, reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also ...