同时,过表达这些 circRNA 还会使 HCMECs 中炎症相关基因(如 IL-1β、IL-6、VCAM-1 ... RNA Pull-Down 实验和双荧光素酶报告基因实验证实了两者的结合,RNA 结合蛋白免疫沉淀(RIP)实验表明这种结合由 AGO2 介导。转染 miR-103a-3p 可降低 circSARS-CV2-N1368 的表达水平,反之亦然。
siMecA-AGO2 complex inhibits the translation of the mecA gene which encodes the penicillin-binding protein 2a (PBP2a), a protein at the heart of the drug-resistance phenotype in MRSA. By reducing ...