Insilico Medicine (“Insilico”) announces that the team, with the support of its generative chemistry engine, has developed a novel and highly selective FGFR2/3 dual inhibitor, which maintains efficacy ...

A 26-residue peptide identified by phage display specifically bound FGF receptor (FGFR) 1c extracellular domain but had no homology with FGFs. When fused with the c-jun leucine zipper domain ...

Fibroblast growth factor receptors (FGFRs) are critical drivers of oncogenesis in various solid tumors, including urothelial carcinoma, hepatocellular carcinoma, ovarian cancer and lung adenocarcinoma ...

It also exhibited robust selectivity, sparing FGFR1/4, and showed minimal off-target effects against a broad panel of kinases. In preclinical models, compound 10 displayed favorable ...

The green light from the European Commission comes a few months after pan-FGFR inhibitor Balversa (erdafitinib) was cleared for the same indication in the US, with a different label than the drug ...

Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision ...

The company's lead drug, TYRA-300, is designed to minimize toxicities associated with FGFR inhibition and is expected to enter Phase 2 studies for various conditions. While InvestingPro analysis ...

GU ASCO annual meeting featured a session on the ABCs of antibody drug conjugates and a presentation by Dr. Di Maria Jiang discussing the targeting of bladder cancer with antibody drug conjugates. Dr.

Expression of Trop2, Nectin-4, and FOLR1 cell surface markers in biliary tract cancers: Is it time to repurpose drugs? This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers ...